Severe Post-thrombotic Syndrome is Associated With Higher Levels of Factor VIII

Luis Fernando Bittar, MSc, Erich V. de Paula, MD, PhD, Silmara A. L. Montalvao, MSc, Tayana B.T. Mello, MD, PhD, and Joyce M. Annichino-Bizzacchi, MD, PhD

Deep venous thrombosis (DVT) is a multifactorial disease, and increased levels of coagulation factor VIII (FVIII) have been established as a risk factor for DVT.1-4 The main determinants of FVIII in plasma are the von Willebrand factor (VWF) and the ABO blood group…