Clinical implications of the detection of antibodies directed against domain 1 of β2-glycoprotein 1 in thrombotic antiphospholipid syndrome

Silmara Montalvão, Priscila Soares Elídio, Sabrina da Silva Saraiva, Bruna de Moraes Mazetto, Marina Pereira Colella, Erich Vinícius de Paula, Simone Appenzeller, Joyce Annichino-Bizzacchi, Fernanda Andrade Orsi, MD, PhD

Antiphospholipid syndrome (APS) is an autoimmune thrombotic disease  characterized by clinical manifestations of vascular thrombosis or pregnancy morbidity and persistent antiphospholipid antibodies (aPL) in serum, such as: lupus anticoagulant (LAC), IgM/IgG anticardiolipin (aCL) or IgG anti-β2 glycoprotein 1 (aβ2GP1)…