Polymorphisms and Mutations in vWF and ADAMTS13 Genes and Their Correlation With Plasma Levels of FVIII and vWF in Patients With Deep Venous Thrombosis

Luis Fernando Bittar, Erich Vinıcius de Paula, MD, PHD, Tayana B. T. Mello, MD, PHD, Lucia H. Siqueira, Fernanda L. A. Orsi, MD, PHD, and Joyce M. Annichino-Bizzacchi, MD, PHD

Deep venous thrombosis (DVT) is a multifactorial disease, and increased levels of coagulation factor VIII (FVIII) had been demonstrated as risk factor for first1 and recurrent2,3 episodes of DVT. The main determinants of FVIII in plasma are the von Willebrand factor (vWF)…